【摘要】 目的观察针箭颗粒对自发性高血压(SHR)大鼠左室肥厚(LVH)的治疗作用并探讨其可能机理。方法取13周龄SHR大鼠40只随机分为针箭颗粒高、中、低剂量治疗组与卡托普利组及模型对照组五组,另取WKY大鼠6只为正常对照组;各组实验8周后进行血压、左室重与体重比(LVM/BW)及循环和局部血管紧张素II(AngII)浓度(放免法测定)的组间比较。结果21周龄时SHR大鼠LVM/BW显著高于WKY大鼠,治疗后各治疗组血压均显著下降,针箭颗粒高、中剂量组及卡托普利组LVM/BW、心肌局部AngII浓度均明显降低;LVM/BW与血压及循环AngII无明显相关,而与心肌局部AngII明显正相关。结论针箭颗粒降低SHR大鼠血压的同时显著逆转其LVH,其作用机理可能主要与降低心肌局部肾素血管紧张素系统(RAS)活性有关。更多还原

【Abstract】 Objective:To observe the effect of Zhenjian Granlue (针 箭 颗 粒 ) on the spontaneous hypertension rats (SHR) with left ventricular hypertrophy (LVH) and to explore the possible mechanism.Methods:40 spontaneous hypertension rats of 12 weeks old were divided into 5 groups treated with high dosage Zhenjian Granlue,middle dosage of Zhenjian Granlue,low dosage of Zhenjian Granlue,captopril and physiological saline respectively,at the smae time 6 Wistar- Kyoto (WKY) rats were regarded as control group.After 8 weeks’ treatment,compared their SBP,LVM/BW,plasma angiotensin Ⅱ and myocardium angiotensin Ⅱ .Results:LVM/BW of SHR was considerable higher than that of WKY rats.After treatment.SPB of 5 treat groups reduced significantly,LVM/BW,myocardium angiotensin Ⅱ reduced significantly in rats treated with high dosage of Zhenjian Granlue middle dosage of Zhenjian Granlue and captopril.There was no apparent relationship between LVM/BW,SBP and plasm a angiotensin Ⅱ ,but LVM/BW and myocardium angiotensin Ⅱ had apparent relationship.Conclusion:Zhenjian Granlue can reduce SBP as well as considerably improve LVH,the functional mechanism is not the improvement of blood dynamics and the e ffect on RAS,but the lower of the activity of myocardium angiotensin Ⅱ .更多还原