【摘要】 目的:比较厄贝沙坦与依那普利对轻中度高血压病患者的降压疗效。方法:采用随机、单盲研究方法。经1周的清洗期,70例坐位舒张压>90 mmHg的高血压患者被随机分入厄贝沙坦组(n=35)150 mg.d-1或依那普利组(n=35)10 mg.d-1,两组均于早晨口服1次。4周末,如坐位舒张压仍>90 mmHg,加用双氢氯噻嗪12.5mg.d-1,总疗程8周。结果:厄贝沙坦组平均坐位收缩压与舒张压分别降低12.0%与15.5%,而依那普利组分别为12.3%与13.9%。厄贝沙坦组有效率73.5%,依那普利组67.6%,无显著性差异(P>0.05)。两组不良反应发生率无显著差别,但依那普利组咳嗽发生率(14%)显著高于厄贝沙坦组(3%)。结论:轻中度高血压的治疗中,厄贝沙坦与依那普利疗效相似且耐受性良好。厄贝沙坦咳嗽发生率低。更多还原

【Abstract】 Objective:To assess the effect of irbesartan versus enalapril in patients with mild-to-moderate hypertension.Methods:A randomized,single-blind parallel arm clinical study enrolled 70 patients with sitting diastolic blood pressure (SDBP)>90 mmHg,who were randomly 1∶1 to receive either irbesartan 150 mg once daily or enalapril 10 mg once daily for 8 weeks after one-week wash out period.At the end of the 4-week of the therapy,hydrochlorothiazide 12.5 mg/day was added onto the patients who still had a SDBP more than 90 mmHg.Results:Irbesartan vs.enalapril significantly reduced mean sitting systolic blood pressure(SSBP) and SDBP of 12.0% vs.12.3% and 15.5% vs.13.9%,respectively.The efficacy rate of irbesartan and enalapril was 73.5% vs.67.6%(P>0.05).The incidence rate of overall adverse events showed no statistical difference in both groups except cough(14% for enalapril vs.3% for irbesartan).Conclusion:Irbesartan was therapeutically equivalent to enalapril in the treatment of mild to moderate hypertension.更多还原