【摘要】 目的:研究马蔺子素脂质体的体外药剂学性质。方法:采用反相蒸发(REV)法制备马蔺子素脂质体,建立马蔺子素的HPLC含量测定法。检验其各项物理化学性质,考察其稳定性与体外释放。结果:马蔺子素脂质体包封率达到98%以上,粒径在100nm左右,3个月内稳定性良好,体外释放48h不超过30%。结论:所制得的马蔺子素脂质体的物理化学性质优良,稳定性良好,体外释放较缓慢。更多还原

【Abstract】 Objective: To characterize the irisquinone liposomes in vitro. Methods: Irisquinone liposomes prepared by the REV technique were quantified by HPLC. The physicochemical characteristics including the stability and drug release in vitro were determined. Results: The encapsulation rate of irisquinone achieved more than 98 percent with the particle size around 100nm. Irisquinone Iiposomes remained stable for 3 months and showed a drug release rate of less than 30% within 48 hours in vitro. Conclusion :The stable irisquinone liposomes have advantages of sustained release.更多还原