【摘要】 目的观察和评价国产GK型双叶式人工心脏瓣膜(GK双叶瓣)植入人体后的早期临床疗效和近期随访结果。方法对61例心脏瓣膜病变患者行人工心脏瓣膜置换术,其中二尖瓣置换术(M VR)34例,主动脉瓣置换术(AVR)16例,二尖瓣和主动脉瓣双瓣膜置换术(M VR+AVR)11例。共植入GK双叶瓣72枚,其中二尖瓣45枚,主动脉瓣27枚;术后监测血液相容性和血流动力学指标,并定期随访和检查是否有与瓣膜相关的并发症发生。结果全组无手术死亡(术后30d内);随访61例,随访1年至2年6个月,远期因外伤死亡1例;其余60例患者术后心功能均从Ⅲ~Ⅳ级转为Ⅰ~Ⅱ级,血流动力学性能及生物相容性良好,生活质量改善。结论GK双叶瓣早期临床应用获得了满意的效果,其近期随访未发现与瓣膜相关的并发症,中、远期结果有待进一步随访观察。更多还原

【Abstract】 Objective To introduce a new type of bileaflet mechanical prosthetic heart valve(GK bileaflet valve)and evaluate clinically the early hemodynamic effect and short term follow-up after its replacement.Methods(Sixty-one) patients with heart valve diseases were operated upon.The mitral valve replacement was performed in 34 patients,aortic valve replacement in 16 patients and double valve replacement in 11 patients.A total of 72 GK bileaflet mechanical valves were implanted,45 in mitral position,and 27 in aortic position.Blood consistency and hemodynamics were monitored.Followup was carried out routinely to check whether there were some valve-related complications.Results There was no early mortality(<30 d).Only one patient died of trauma 2 months after the operation.Follow-up was 100% and extended 1 to 2.5 years.Without valve-related complications all patients had lived for more than 1 to 2.5 years.In 98%(60/61) of survivors heart functional performance had improved to New York Heart Association class Ⅰ or Ⅱ.Conclusion Early clinical results and short-term follow-up demonstrate that GK bileaflet prosthetic heart valve exhibits excellent hemodynamic properties,satisfied blood consistency and a low incidence of valve-related complications.Midterm and long-term results should be observed further.更多还原