【摘要】 目的:研究强迫症患者探究性眼球运动及其与临床的关系。方法:对符合DSM-IV诊断标准的57例强迫症(其中27例无用药史,30例有用药史)和50例在性别、年龄和受教育水平方面与之相匹配的正常人进行探究性眼球运动检查,并分析探究性眼球运动与临床的关系。结果:强迫症患者的探究性眼球运动多数指标均低于正常人(P<0.05或者P<0.01);强迫症患者差别分析值正分者占37%,而正常对照组为8%,两者差异具有统计学显著性(!2=12.27,P<0.001)。以眼球运动指标为因变量并以临床变量为自变量进行多元逐步回归分析,在α=0.05水平,被选入反应性探究分回归方程者有思维形式障碍(如赘述);选入认知性探究分回归方程者为强迫症状诱发因素、病程、精神运动迟缓分、Mausley强迫症状总分。结论:强迫症患者探究性眼球运动异常,支持强迫症额叶皮层-基底节异常学说,强迫症与精神分裂症在生物学上存在某些关联或者重叠。更多还原

【Abstract】 Objective:To investigate the eye movement anormalities of Obsessive-Compulsive Disorder (OCD) and their possible clinical significances. Methods: Exploratory eye movement in 57 patients with OCD according to DSM-IV criteria (27 medicated, 30 un-medicated) and 50 normal controls matched with sex, age and education were examined respectively. Results: Compared with normal controls, patients with OCD demonstrated low scores in most of the indices of exploratory eye movement. The rates of positive discrimiant score in OCD and normal controls were 37%(21/57) and 8% (4/50), respectively (X2 = 12.27, P<0.001). Step-wise Regression analysis, the indices of exploratory eye movement as the dependent and the clinical variables as the independent(α= 0.05), found that thought patterns (such as circumstantiality) entered the RSS(Responsive Search Score) equation; Cue of symptoms, course of illness, slowness or retardation in Y-BOCS, total score of Mausley Obsessive-Compulsive Scale entered the CSS (Cognitive Search Score) equation, respectively. Conclusion: There are abnormalites of exploratory eye movement in patients with OCD. Our findings confirmed the theroy of frontal-striatal circuity of OCD and there seems to be some relationship or overlap between OCD and schizophrenia in neurobiology.更多还原