【摘要】 目的:比较利培酮和奎硫平对首发精神分裂症患者认知功能的影响。方法:采用随机对照研究连续观察12周,利培酮组32例,剂量范围为1～7mg/d,奎硫平组35例,剂量范围25～750mg/d。进行PANSS、韦氏记忆量表（WMS）和事件相关电位P₃₀₀检查。结果:首发精神分裂症患者的长时记忆、短时记忆、瞬时记忆及记忆商数（MQ）受损较为明显,与对照组比较差异有显著性（P<0.05）。P₃₀₀电位成分中P₂、N₂及P₃潜伏期明显延长,P₂及P₃波幅明显降低,与对照组比差异均有显著性（P<0.05）。经过12周治疗,奎硫平和利培酮组PANSS 总分、阳性症状分、阴性症状分及一般精神病理症状分均降低,两组相比差异无显著性（P>0.05）,说明两药的疗效相当。服用奎硫平及利培酮治疗的患者WMS 的再认、联想、理解及记忆商（MQ）均明显高于治疗前,治疗后两组患者WMS 各项目之间比较差异均无显著性（P>0.05）;两组在治疗前后P₃₀₀各指标之间差异无显著性。结论:首发精神分裂症患者存在着认知功能障碍,奎硫平与利培酮对改善首发精神分裂症认知功能的作用相当。更多还原

【Abstract】 Objective:To compare the effects of quetiapine and risperidone on cognitive function of first-episode schizophrenic patients.Methods:A randomized comparative clinical design was applied to compare the cognitive function of 67 patients with first-episode schizophrenia treated with quetiapine（n=35,25-750mg/d）and risperidone（n=32,1-7rag/d）before and after 12-week treatment.PANSS,WMS and P300 were used to evaluate adverse effects of drags and cognitive function.Results:The Long-term memory,Short-term memory,Immediate memory,Memory Quotient of first-episode schizophrenia were damaged obviously.Latency periods of P₂、N₂ and P₃ of P₃₀₀ potentials with first-episode schizophrenia group were longer than the control group,The amplitudes of P₂ and P₃ of P₃₀₀ potentials with first-episode schizophrenia group were lower than the control group（P<0.05）.After 12-week treatment,some of the scores in two groups were decreased significantly,including total scores of PANSS,scores of positive symptom scores,negative symptom and general psychopathology subscales.The decreased rate had no significant differences between the two groups,which indicated a similar effectiveness in both groups.In both groups, the Recognize,Association,Comprehend,MQ of WMS were significantly higher after treatment,while no differences in WMS and P300 between risperidone and quetiapine groups after treatment.Conclusion:The presence of cognitive dysfunction in first-episode schizophrenia has been confirmed.The study suggests that both quetiapine and risperidone can improve cognitive function of first-episode schizophrenic patients更多还原