【摘要】 [目的]观察青芪散对免疫损伤小鼠的免疫调节作用。[方法]中药复方制剂青芪散小、中、大3个剂量治疗冻干卡介苗(BCG)加脂多糖(LPS)免疫性肝损伤小鼠,与迈普新(Tα1)对照,观察其对淋巴细胞亚群、白细胞介素2(IL2)及肝脏病理的影响。[结果]青芪散中剂量组显著降低CD8+,提高CD3+、CD4+及CD4+/CD8+比值,与Tα1组比较差异有统计学意义(P<0.05);对肝组织病理学影响,中剂量组与Tα1组比较稍优,但无统计学意义(P>0.05)。[结论]青芪散有明确的免疫调节作用。更多还原

【Abstract】 Objective]To study the effect of Qingqi granules (QG) on lymphocyte subset and interleukin-2 of mice. [Methods] The mice models were made by injury bacillus Calmette-Guerin (BCG) plus lipopolysaccharide (LPS), then treated by low, medium and high dosages of QG respectively, controlled with the Thymosin α1. Effects of QG on lymphocyte subset and interleukin-2 and pathology of liver tissue were observed. [Results] The serum CD8~+ lymphocyte was significantly decreased and CD3~+,CD4~+,CD4~+/CD8~+ was significantly increased by QG medium dosage than those in the control group(P<0.05). Pathology changes of liver tissue were better in QG medium dosage group than those in the control group without statistical significance (P>0 05). [Conclusion]QG can adjust immunity.更多还原