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肝炎平对大鼠肝纤维化血清学指标的影响

Effect of Ganyanping on Serum Indexes of Liver Fibrosis Induced by CCl4 in Rats

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【作者】 唐望先晏维舒柏华张芳杰高啸郭燕

【Author】 TANG Wang-xian1 YAN Wei1, SHU Bo-hua2, et al. 1.Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhing University of Science and Technology(Wuhan Hubei,430030) China 2. Institute of Environmental Health Science, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology

【机构】 华中科技大学同济医学院同济医院肝病研究所华中科技大学同济医学院公共卫生学院环境医学研究所华中科技大学同济医学院同济医院肝病研究所 (湖北武汉430030)(湖北武汉

【摘要】 目的:探讨肝炎平对肝纤维化大鼠血清中肝纤维化指标的影响。方法:制备大鼠肝纤维化模型。动物随机分为正常对照组(N组)、肝炎平治疗组(G组)、和络舒肝胶囊治疗组(H)及肝纤维化模型组(M组)。采用放射免疫法对大鼠血清肝纤维化指标透明质酸(HA)、Ⅳ型胶原(CⅣ)、板层素(LN)及Ⅲ型前胶原(PCⅢ)进行检测,并观察大鼠肝脏组织学变化。结果:肝炎平组及和络舒肝组能明显降低肝纤维化大鼠的HA、CⅣ、LN及PCⅢ水平,与模型组比较,差异有显著性意义(P<0.05),两组大鼠肝脏组织病理学变化亦有明显改善。结论:肝炎平具有抗大鼠肝纤维化的作用。

【Abstract】 Objective:To study the effect of Ganyanping on four serum indexes of liver fibrosis. Methods: The rats were separated randomly into four groups: normal group(N), Ganyanping-treating group(G) and Huoluoshugan-treating group(H), and model group(M).The pathological changes of livers were observed. The four serum indexes of liver fibrosis, including hyaluronic acid(HA), collagen Ⅳ(C-Ⅳ).laminin(LN) and precollagen type Ⅲ (PC-Ⅲ),were evaluated by radioimmunoassay. Results: The serum levels of HA, C-Ⅳ,LN and PC-Ⅲ in Ganyanping-treating group and Huoluoshugan-treating group were obviously decreased.There were significant difference with model group(P<0.05) and the pathological change of Ganyanping-treating group and Huoluoshugan-treating group were improved.Conclusion:[WTBZ] Ganyanping has the antifibrotic effect on liver fibrosis of rats by reducing the degree of serum HA, C-Ⅳ, LN and PC-Ⅲ.

【基金】 国家自然科学基金课题专项基金(No.30440088)
  • 【文献出处】 中西医结合肝病杂志 ,Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases , 编辑部邮箱 ,2005年06期
  • 【分类号】R285
  • 【下载频次】54
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