【摘要】 目的:初步探讨大剂量乙肝疫苗穴位注射治疗HBV携带者(AsC)的临床效果及其机制。方法:将140例AsC随机分为治疗组90例和对照组50例。治疗组给予乙肝疫苗60~180μg穴位注射,每周1次。对照组给予α-干扰素2.0×106IU~3.0×106IU肌肉注射,隔日1次。疗程均为6个月。结果:治疗组90例中HBeAg和HBV DNA的转阴例数分别为51例和56例,对照组50例中有8例HBeAg和12例HBV DNA转阴,两组比较差异有显著性意义(P<0.05)。结论:大剂量乙肝疫苗穴位注射是通过针、药、穴和经络的相互作用,产生综合效能,抑制HBV的复制和提高免疫应答,进而清除HBV。是治疗AsC安全有效的疗法。更多还原

【Abstract】 Objective:To explore the clinical effect and mechanism of massive dose of hepatitis B vaccine on hepatitis B viral carrier.Methods:140 patients were randomly divided to treatment group and control group.Treatment group were received an injection of 60～180μg hepatitis B vaccine once a week,and control group were received an injection of 2.0×10~6～3.0×10~6IU interferon α once every two days,both with a course of six moths.Results:51 HBeAg and 56 HBV DNA of the 90 cases in the treatment group turned negative while only 8 patient’s HBeAg and 12 patients’ HBV DNA of the 50 cases in the control group turned negative.The difference in treatment effects between the two groups were statistically significant(P<0.05).Conclusion:Point-injection therapy by massive dose of hepatitis B vaccine have an synthetic effect on improving immune response,clearing away HBV and blancing the immunity of the body,it is realized through the interaction of acupuncture and moxibustion,pharmacotherapy,point-stimulating therapy and meridian.So,it can become safe and effective therapy for treating hepatitis B viral carricer.更多还原