【摘要】 目的探讨辛伐他汀干预对急性冠脉综合征(ACS)患者血清白细胞介素-6(IL-6)和高敏C反应蛋白(hs-CRP)浓度的影响及他汀治疗ACS的机制。方法分别测定50例ACS、34例稳定型心绞痛(SA)患者及30例正常对照者(NC)血清IL-6、hs-CRP水平;并将ACS组分辛伐他汀组和常规组进行干预,随访3周,再次测定血清IL-6及hs-CRP水平;分析比较组间及辛伐他汀治疗前后血清IL-6及hs-CRP水平。结果ACS组血清IL-6、hs-CRP水平明显高于SA及NC组(P<0.001)。干预后,辛伐他汀组血清IL-6、hs-CRP浓度明显下降(P<0.001)。结论辛伐他汀具有独立于降脂的抗炎作用,其抗炎作用在ACS患者早期治疗中可能具有重要意义。更多还原

【Abstract】 【Objective】To explore the effect of simvastatin on serum levels of interleukin- 6 and high- sensitivityC- reactive in patients with acute coronary syndrome (ACS) and the mechanism by which statin treat ACS.【Method】The serum high- sensitivity C- reactive protein (hs- CRP) and interleukin- 6 (IL- 6) levels were measuredin 50 patients with ACS, 34 patients with stable angina (SA) and 30 controls. Patients in ACS group were randomlyassigned to the simvastatin group (n =25) and the routine group (n =25). The simvastatin group was given simvastatin20 mg per day and the routine group took placebo. After a three- week follow- up, serum hs- CRP and IL- 6 levelswere measured again.【Results】Both serum IL- 6 and hs- CRP levels were significantly higher in ACS group than inSA and Normal Controls (NC) group (P <0.001). After three- week treatment with simvastatin, serum IL- 6 and hs-CRP were decreased significantly in the simvastatin group (P <0.001).【Conclusion】Simvastatin possess anti- in-flammatory effect which independent of its lipid- lowering action, and the anti- inflammatory effect of simvastatin mayplay an important role in the early treatment of ACS.更多还原