【摘要】 目的了解非糖尿病肾病慢性肾衰竭(CRF)患者胰岛素抵抗与其出现的高血压、脂代谢紊乱和高尿酸血症的关系。方法测定92例CRF患者的空腹血糖、空腹胰岛素、血压、血脂及血尿酸等指标。计算胰岛素敏感指数(ISI)——空腹血糖与空腹胰岛素浓度乘积的倒数。分别比较伴和不伴高血压、高甘油三脂血症、高胆固醇血症、高尿酸血症CRF患者的ISI。结果伴有高血压、高甘油三脂血症、高尿酸血症的CRF患者的ISI明显降低(P<0.05);伴和不伴高胆固醇血症的CRF患者ISI差异无显著意义(P>0.05)。结论胰岛素抵抗参与了CRF患者高血压、高甘油三脂血症和高尿酸血症的发生。更多还原

【Abstract】 To investigate the relationship between insulin resistance(IR) and hypertension, dyslipidemia, hyperuricemia in non-diabetic nephropathy chronic renal failure(CRF). Plasma glucose, insulin, blood pressure, lipid and uric acid were measured in 92 patients with CRF. The reverse of fasting plasma glucose and insulin product were used as an index of IR. Insulin sensitivity index(ISI) was compared between CRF with and without hypertension, hypercholesterolemia, hypertriglyceridemia, hyperuricemia. ISI decreased obviously in CRF with hypertension, hypertriglyceridemia, hyperuricemia (P <0.05). There was no differentiation of ISI in CRF with and without hypercholesterolemia. [Conclusion] IR is involved in hypertension, hypertriglyceridemia, hyperuricemia in non-diabetic nephropathy CRF .更多还原