【摘要】 目的评价活性炭纳米粒指导胃癌淋巴结清扫的临床应用价值。方法32例胃癌患者术前或术中肿瘤周围注射活性炭纳米粒混悬液,比较其清扫淋巴结的数目、淋巴结黑染及转移情况,并观察副作用的发生。结果活性炭组每例患者清扫的淋巴结数(32.7±11.4枚)明显高于对照组(17.0±8.7枚),主要是清扫的N2淋巴结数明显增多(23.1±8.0枚):(8.7±4.2枚);活性炭组黑染度为58.2%,N1淋巴结的黑染度(66.7%)较N2(49.8%)高;黑染淋巴结中发生淋巴结转移的阳性率(20.7%)明显高于未黑染淋巴结(3.7%)及对照组(15.2%);活性炭组手术时间稍延长,但手术并发症未增加;局部组织注射活性炭纳米粒未见严重副作用发生。结论肿瘤周围局部注射活性炭纳米粒是一种有效、易行和安全的方法,对胃癌淋巴结清扫有指导作用。更多还原

【Abstract】 To evaluate the clinical applied value of activated carbon nanoparticles to guide gastric cancer lymphadenectomy. 32 cases of gastric cancer received activated carbon nanoparticles injection around the tumor by preoperative submucosal endoscopic injection or intraoperative subserosal injection. The number of dissected lymph nodes, black-stained lymph node, positive lymph node and the side effect of the procedure were analyzed respectively. The average lymph nodes resected was higher in activated carbon(AC) group (32.7±11.4) than in control group (17.0±8.7), especially in N2 (23.1±8.0 ) than in N1(8.7±4.2). The total black-stained ratio of lymph node was 58.2%, with N1(66.7%) and N2 (49.8%) in AC group. The positive rate of lymph node was higher in black-stained lymph node of AC group (20.7%) than in unstained lymph node of AC group(3.7%) and control group(15.2%). The operative periods was slighted longer in AC group than in control group, with same operative complications. No serious side effect happened of activated carbon nanoparticles injection in local gastric tissue. [Conclusions] Local injection of activated carbon nanoparticles around the tumor is an effective, easy and safe procedure to guide gastric cancer lymphadenectomy.更多还原