【摘要】 目的 :了解浙江绍兴地区临床分离的主要革兰阴性病原菌的耐药情况。方法 :采用Kirby -Bauer法对浙江省绍兴地区 2 0 0 2～ 2 0 0 3年分离的 15 95株革兰阴性杆菌进行药物敏感试验。采用双纸片法检测上述菌株产生的超广谱 β -内酰胺酶。结果 :上述革兰阴性杆菌最为敏感的抗生素为碳青酶烯类抗生素亚胺培南 (95 5 % ,965 / 10 10 )和美洛培南(94 6% ,95 4/ 10 0 8) ,其次是派拉西林 /他唑巴坦 (93 8% ,64 0 / 682 ) ,敏感性最低的抗生素为头孢噻吩 (15 8% ,2 3 8/15 0 8)。 2 5 4% (4 0 / 15 7)和 2 6 1% (4 1/ 15 7)的铜绿假单胞菌菌株对美洛培南和亚胺培南耐药。大肠埃希菌对环丙沙星的耐药率高达 61 3 % (4 10 / 669)。 13 2 %的大肠埃希菌 (89/ 675 )和 18 4%的肺炎克雷伯菌 (80 / 43 6)为超广谱 β -内酰胺酶菌株 (ESBLs) ,但未发现铜绿假单胞菌和鲍氏不动杆菌有ESBLs菌株。结论 :碳青酶烯类抗生素、派拉西林 /他唑巴坦仍是目前细菌耐药性较低抗生素。但本地区耐碳青酶烯类抗生素的铜绿假单胞菌株 ,以及大肠埃希菌和肺炎克雷伯菌ESBLs菌株已较为常见。更多还原

【Abstract】 Objective:To understand drug resistance of dominant gram-negative pathogenic bacteria isolated from Shaoxing area in Zhejiang province Methods:Drug sensitivity test was performed to examine drug resistance of 1 595 strains of gram-negative bacilli isolated from Shaoxing area during the beginning of 2002 to the end of 2003 by Kirby-Bauer method Extended spectrum beta-lactamase produced by the microbes was detected by using double paper strip method Results:The most sensitive antibiotics tested for the gram-negative bacilli mentioned above was imipenem (95 5%, 965/1010) and meropenem (94 6%, 954/1008), which belonging to carbapenems, and then the piperacillin/tazobactam (93 8%, 640/682) Cephalothin was found to be the lowest sensitive antibiotic (15 8%, 238/1508) 25 4 % (40/157) and 26 1% (41/157) of the P aeruginosa strains showed resistance to imipenem and meropenem Resistant rate to ciprofloxacin of the E coli strains was as high as 61 3% (410/669) 13 2% of the E coli strains (89/675) and 18 4% of the K pneumoniae strains (80/436) were demonstrated to be ESBLs.But no ESBLs could be found in the strains of P aeruginosa and A baumannii Conclusion:Carbapenems and piperacillin/tazobactam remain to be the antibiotics with lower resistance currently However, the strains of P aeruginosa resistant to carbapenems and ESBLs in E coli and K pneumoniae become frequent in the local [更多还原