【摘要】 目的观察亚甲蓝与抑肽酶联合应用对术后腹腔内粘连的防治作用。方法选择2000年5月至2004年2月行全部或部分结肠切除术和暂时性回结肠造口术,8～12周后闭合回结肠造口的患者83例,于第1次手术时将病例随机分为4组:A组不用任何预防粘连药物,用生理盐水冲洗腹腔(对照组);B组关腹前腹腔内给予1%亚甲蓝10ml;C组关腹前腹腔内给予抑肽酶10万U;D组关腹前腹腔内给予1%亚甲蓝10ml及10万U抑肽酶。于第2次手术时观察各组腹腔内粘连程度。结果对照组中粘连发生率为83%,亚甲蓝和抑肽酶组粘连发生率分别为45%和50%;而亚甲蓝加抑肽酶组粘连发生率仅为15%,明显较其他3组低,与之比较,差异有统计学意义(P<0.001)。结论腹腔内给予亚甲蓝或抑肽酶能降低腹腔内粘连的发生率,两者联合用药作用更加显著。更多还原

【Abstract】 Objective To study the effect of methylene blue combined with aprotinin on intraperitoneal adhesion. Methods From May 2000 to February 2004,there were 83 patients receiving total or partial colectomy and temporary ileostomy or colostomy,and second anastomosis was performed within 8～12 weeks after the first operation. These patients were divided into four groups and followed by intraperitoneal administration of saline,methylene blue,aprotinin,combined methylene blue and aprotinin respectively during the second operation, then adhesion formation was quantitatively graded. Results The adhesion rate was 15%in combination group,83%in saline group,40%in methylene blue group,and 45%in aprotinin group,respectively.The adhesion rate was significantly lower in combination group(P< 0.05). Conclusions Methylene blue and aprotinin can decrease the incidence of intraperitoneal adhesion significantly. The combination of these two drugs has significant effectiveness in the treatment of intraperitoneal adhesion.更多还原