【摘要】 为有效利用鲍鱼资源,研究了鲍鱼酶解提取物(Enzymolytic extracts of abalone,EEA)的营养成分及对免疫功能的影响。EEA游离氨基酸总量为8.53gL,第一限制氨基酸为Leu,其氨基酸价为81,牛磺酸含量为7.80gL,磷脂总量为153mgL,富含维生素和Se、Zn等矿物质。EEA可依剂量改善氢化可的松型免疫低下小鼠的体重、胸腺和脾重,增加肝脏DNA和RNA含量以及外周血T细胞比例,提高胸腺和脾脏淋巴细胞增殖能力。EEA对胸腺的作用大于脾脏。结果表明,EEA含有丰富的营养成分,对免疫低下有明显的改善作用,对细胞免疫的作用大于体液免疫,其机制可能是促进免疫细胞DNA的合成。更多还原

【Abstract】 This study was intended to investigate the nutrients in the enzymolytic extract of abalone (EEA) and their effect on immune function. It was determined that the EEA contained free amino acids 8.53 g/L (first limiting amino acid leucine, amino acid score 81), taurine 7.80 g/L, phosphate 153 mg/L, and was rich in vitamins and mineral elements such as Se, Zn. In mice with hydrocortisone-induced immunosuppression, EEA improved the weight of body, thymus, and spleen, increased liver DNA and RNA and peripheral blood T lymphocyte, and enhanced lymphocyte proliferations of thymus and spleen, in a dose-dependent manner. EEAs actions on thymus were more effective than those on spleen. The results indicated that EEA was rich in nutrients and possessed significant immunomodulatory effects, especially on cellular immunity, which was probably related to its promoting activity on DNA synthesis of immunocytes.更多还原