【摘要】 目的观察纳洛酮对脑损伤患者血浆内皮素(ET)、降钙基因相关肽(CGRP)水平的影响。方法用放射免疫测定法测定创伤性脑损伤患者血浆ET-1、CGRP水平变化。结果创伤性脑损伤后血浆ET水平明显升高,病情越重升高越明显。纳洛酮治疗后血浆ET-1水平下降较对照组明显,CGRP早期(1 d)较对照组升高明显。结论创伤性脑损伤后患者血浆ET-1水平升高,且与病情严重程度有关。早期应用纳洛酮可显著降低ET-1和提高CGRP水平,并获得良好治疗效果。更多还原

【Abstract】 Objective To observe the effect of Naloxone on the level of endothelin(ET),calcitonin gene-related peptide(CGRP) in the plasma of patients with traumatic brain injury(TBI).Methods The levels of ET-1,CGRP in the plasma of patients with TBI were evalued by radioimmunoassay.Results The results show that(levels) of ET-1 in the plasma of patient with TB1 increased significantly.The levels of ET-1 deceased markedly(after) the therapy of Naloxone,but levels of CGRP increased significantly,especially in 1 d.Conclusions The levels of ET-1 in plasma clearly increase during the early trauma.The more serous is the TBI,the more obvious is the increasing levels of ET-1.Naloxone take effects by increasing the levels of CGRP and deceasing levels of ET-1 in plasma in patients with TBI.更多还原