【摘要】 亨廷顿舞蹈病(Huntington’s disease,HD)是一种由IT15基因上CAG重复序列异常扩展所致常染色体显性遗传的神经退行性疾病。HD的确切发病机制至今尚不清楚。目前该病尚无有效的治疗方法,在临床上只能给予对症治疗。近年来,关于HD发病机制及治疗方面的研究取得了很大进展。本文对HD的临床对症治疗现状和实验性治疗(包括针对发病机制的治疗、神经保护及替代治疗、环境治疗等)研究进展进行了综述。更多还原

【Abstract】 Huntington’s disease(HD)is an autosomal dominant neurodegenerative disorder,which is caused by an abnormally expanded CAG trinucleotide repeat in the IT15 gene. At present, the mechanism of HD pathogenesis has not been completely understood. There is no effective treatment for HD. In recent years, significant advances have been made in uncovering pathogenic mechanisms and developing potential treatments for HD. In this article, we review the drugs used for treatment of clinical symptoms of HD and the progress in experimental therapies for HD.更多还原