【摘要】 目的:观察灯盏花素不同作用时间对角叉菜胶诱导的血栓模型大鼠血液流变学参数的影响。方法:Wistar大鼠sc角叉菜胶5mg.kg-1复制血栓模型;尾静脉注射36 mg.kg-1灯盏花素后不同时间腹主动脉取血进行血液流变学参数的测定。结果:灯盏花素在药后30min能显著抑制血小板聚集、降低全血黏度,血浆黏度随药物作用时间的延长有降低的趋势;而对红细胞压积和纤维蛋白含量没有显著影响。结论:灯盏花素对血栓模型大鼠血液流变学参数的影响可能是原形药物与代谢产物共同作用的结果。更多还原

【Abstract】 Objective:To observe the effect of scutellarin on hemorheology of rat thrombus model induced by Carrageenan after intravenous administration of scutellarin.Method:The thrombus model was induced by a single sc dose of 1% carrageenan(5mg·kg^-1).The blood sample was collected by the puncture of the abdomen aorta and the effect of scutellarin on hemorheological parameters was observed.Result:Scutellarin inhibited significantly platelet aggregation,depressed the whole blood viscosity and influenced slightly the plasma viscosity,which indicated certain trends with extended action duration,but it did not affect the level of the hematocrit and the fibrinogen.Conclusion:The effect of scutellarin on hemorheological parameters of rat thrombus model induced by Carrageenan was due to interaction of scutellarin and its metabolites.更多还原