【摘要】 目的评估3种不同的联合治疗对慢性乙型肝炎感染的临床疗效。方法慢性乙型肝炎患者120例平均分为3组,第1组为干扰素(INF-)α+乙肝疫苗组;第2组为INF+泛昔洛韦(FCV)组;第3组为INF+拉米夫定(3TC)组,分别治疗6个月。结果(1)治疗后丙氨酸氨基转移酶(ALT)复常率无差异。(2)治疗后第3组乙肝E抗原阴转率和HBV DNA的阴转率明显高于其他两组,差异有统计学意义。而第1、2组间的比较差异无统计学意义。结论拉米夫定与干扰素联合治疗对HBV的抑制作用明显优于其他两种方法。更多还原

【Abstract】 Objective To evaluate the advantages of a therapy combining with interferon-alpha plus second-generation nucleoside analogues(lamivudine or famciclovir),or vaccination in chronic HBV infection.Methods One hundred twenty patients with chronic HBV infection were divided into three groups and were treated with the following combinations: 1)Group one was administrated by: INF-alpha2а, 5 million units for muscle injection every other day for six months;HBV vaccine,30 μg for once a month;2) Group Two was administrated by: IFN-alpha2a as the same as group one,as well as by famciclovir,250 mg or each,three time per day,for six months;3) Group Three was administrated by: IFN-alpha2а,as the same as group one,and lamivudine,for 100mg one a day,for six months. Results 1)There was no significant difference in normalizing rate of ALT among different groups after treatment;2)Some significant differences in negative rate of serum HBV DNA and HBeAg in group 3 comparing with another two groups(P<0.05) was found.Conclusion The combination of IFN-alpha with lamivudine is more effective than the combination of IFN-alpha with HBV vaccination or famciclovir.更多还原