【摘要】 山茛菪碱类化合物具有M胆碱受体抑制剂的作用,有潜在的药物研究价值。合成了新的山茛菪碱衍生物,采取电喷雾离子阱质谱的正、负离子模式对3种苄基修饰的山茛菪碱季铵盐进行了质谱分析。实验表明,负离子模式下,山茛菪碱季铵正离子与两个氯离子结合形成[M+35]-准分子离子峰,并在二级质谱中生成失去一氯甲烷或苄基氯的离子。正离子模式下的一级质谱中,3种衍生物均产生山茛菪碱季铵基正离子峰[M35]+;二级质谱中,连接苄基的CN键与HOC、HC或RCOOC键协同断裂,产生托品骨架离子。本研究进一步分析了N苄基山茛菪碱季铵盐的结构特征,揭示了该类季铵盐的质谱裂解特征。更多还原

【Abstract】 Anisodamine shows activity as cholinoceptor blocking agent. Some new anisodamine derivatives were synthesized. To confirm the structures of those derivatives, their mass spectrometries were studied through electrospray ionization-ion trap mass spectrometer. The results indicated that anisodamine derivatives modified by benzyl, the quaternary ammonium chloride, could form a molecular-related ion [M+35]- and producted ions through elimination of methyl chloride or benzyl chloride in spectra of negative ion mode. In positive ion mode, ESI-MS spectra of three compounds all gave molecular-related ions [M-35]+. Their MS 2-4spectra gave the characteristic product ions which were also formed by the cleavage of C-N bond accompanied with breaking of HO-C, H-C or RCOO-C bonds of the quaternary ammonium cation of compound a-c.更多还原