【摘要】 目的探讨胰十二指肠切除术后胰瘘发生的危险因素。方法回顾性分析我院1994年12月至2003年12月期间接受胰十二指肠切除术的连续123例患者的临床资料。结果本组胰瘘的发生率为11.4%(14/123)。单变量分析结果表明:上腹部手术史、胰腺质地、术后血红蛋白、胰肠吻合方式及胰管直径为有意义的相关因素;经Logistic回归多变量分析确定了4个独立与胰瘘相关的变量,即上腹部手术史、胰腺质地、术后血红蛋白及胰肠吻合方式。结论上腹部手术史、胰腺质地软、术后血红蛋白<90g/L及常规套入式胰肠吻合为胰十二指肠切除术后胰瘘发生的主要危险因素。更多还原

【Abstract】 Objective To determine the risk factors associated with development of pancreatic fistula after pancreatoduodenectomy (PD). Methods The clinical data of 123 consecutive patients who underwent PD from Dec. 1994 to Dec. 2003 were analysed retrospectively. Results The incidence of pancreatic fistula was 11.4% (14/123). Univariate analysis showed history of upper abdominal operation, texture of pancreas, postoperative serum hemoglobin level, type of pancreatojejunostomy and diameter of pancreatic duct were significantly associated with pancreatic fistula after PD. Multivariate analysis using Logistic regression identified four variables as independent factors associated with the occurrence of pancreatic fistula: history of upper abdominal operation, texture of pancreas, postoperative serum hemoglobin level and type of pancreatojejunostomy. Conclusion History of upper abdominal operation, soft texture of pancreas, postoperative serum hemoglobin level less than 90 g/L and routine invaginated pancreaticojejunostomy are main risk factors associated with development of pancreatic fistula after PD.更多还原