【摘要】 目的寻找影响Ⅱ期大肠癌预后的危险因素,为该期患者应用辅助化疗提供参考。方法回顾性研究了136例腹膜返折以上未进行辅助化疗的Ⅱ期大肠癌患者,利用Cox回顾模式,通过对其5年生存率和生存时间的研究,筛查影响预后的可能危险因素。结果65例男性和71例女性,平均年龄58岁,平均随访时间104.5个月。5年生存率为83.3%。通过多因素分析,出现梗阻症状、神经受侵犯、术中清扫淋巴结<10个差异有显著性。结论具有1个或以上的危险因素的患者为高危患者,对于该人群患者可以考虑行术后辅助化疗。更多还原

【Abstract】 Objective To further explore the potential benefits of adjuvant chemotherapy to these patients, it is important to identify the subgroup of patients with the high risk of relapse in the first place. Methods We retrospectively studied 136 patients with stage Ⅱ colorectal cancer. The Cox regression model was used to screen the prognostic factors according to the survival time. Results We analyzed 65 men and 71 women with a mean age of 58, the median follow- up was 104.5 months, and the 5 year survival rate was 83.3 %. In multivariate analysis, the presence of obstruction, neural invasion and the number of dissected lymph nodes showed significant poor prognosis. We defined this group with a significant lower 5-year survival rate and overall survival time as high risk. Conclusions With these factors, we can evaluate patients with poor prognosis, and consideration of adjuvant chemotherapy should be given to these patients so that they may benefit from chemotherapy.更多还原