Objective To study the relationship between expression of EGFR and E- cadherin and metastasis of esophageal cancer. Methods The expression of EGFR and E- cadherin in esophageal cancer tissues of 47 patients by LSAB immunohistochemistry method was studied. Results The positive rates of EGFR in distant metastasis group and local lymph node metastasis group were 47.62 % and 56.52 % respectively. They were higher than individual corresponding control groups(27.08 % and 26.32 %)(P<0.05); The EGFR expressive rate...
【更新日期】
2005-08-31
【分类号】
R735.1
【正文快照】
0引言近年来,食管癌的生物学及分子病理学研究发展迅速,由原癌基因c-erbB-1所编码的表皮生长因子受体(epiderm al growth factor receptor,EG FR),因具有促进肿瘤细胞生长和转移的作用[1]日益受到人们关注;而介导细胞间连接的重要黏附分子上皮型钙黏附素E-cadherin与肿瘤的浸润