【摘要】 目的　探讨全反式维甲酸对大鼠C6脑胶质瘤的诱导分化效应及其机制。方法　建立大鼠 C6脑胶质瘤模型,腹腔注射全反式维甲酸后,MRI检测胶质瘤的体积变化及流式细胞仪检测细胞增殖时相变化。结果　治疗组较对照组MRI检测显示肿瘤体积减小(P<0.05 ),流式细胞仪检测显示G1期细胞比例增加(P<0.05),S期细胞比例减少 (P<0.05)。结论　全反式维甲酸可诱导C6胶质瘤分化,显著抑制胶质瘤细胞增殖,且其机制与改变细胞周期有关。更多还原

【Abstract】 Objective To evaluate the effect and mechanism of the inducing differentiation of all trans retinoic acid in the rat C6 glioma. Methods By establishing rat C6 glioma brain tumour model,after delivering all trans retinoic acid via syringe injection into the peritoneal cavity,MRI and flow cytometer were employed to inspect tumour volume and cell cycle respectively. Results Tumour volume in the treatment group was smaller than that in the control group （P<（0.05））,the ratio of the cells at G₁ phase relatively increased（P<（0.05）） and S phase relatively decreased（P<（0.05）） in the treatment group as compared with that of the control group.Conclusion All trans retinoic acid can induce differentiation and inhibit proliferation on rat C6 glioma,its mechanism is concerned with the changes of the cell cycle.更多还原