【摘要】 目的探讨湖北钟祥河南移民与湖北本地居民食管鳞状细胞癌组织中人乳头状瘤病毒(humanpapillomavirus,HPV)感染的情况。方法应用免疫组化SP方法,检测82例食管癌组织中PV和HPV感染情况。以正常食管手术残端黏膜组织作正常对照。结果钟祥食管癌高发区、麻城地区、湖北省肿瘤医院标本中PV阳性感染率分别为75%、68.18%、72.5%。HPV分别为45%、36.36%、37.5%。PV、HPV的阳性表达与食管鳞癌具有显著相关(P<0.05),正常食管黏膜组织中PV、HPV均为阴性。结果未发现PV、HPV阳性细胞与食管癌细胞分化程度有明显相关性(P>0.05)。在三组研究对象之间PV、HPV的阳性率未显示统计学差异(P>0.05)。结论湖北钟祥河南移民及湖北其他地区居民食管癌组织中可能存在HPV感染。HPV在一定的地域环境中与食管癌发生、发展的关系可能具有普遍意义。更多还原

【Abstract】 Objective To investigative the HPV infection in esophageal carcinoma in Henan emigration of Hubei Zhongxiang and Hubei native residenter, and their relations to progression of esophageal carcinoma. Methods Immunohistochemical analysis was performed in 82 human esophageal carcinoma tissue. The adjacent normal esophageal mucosa was used as normal controls. Results The PV positive rate was 75%, ~68.18% and ~72.5% , respectively in esophageal carcinoma tissues from Zhongxiang, Hubei Macheng and Hubei cancer hospital. The HPV positive rate was 45%, ~36.36% and ~37.5% , respectively. The PV and HPV were negative in all the adjacent normal esophageal mucosa. No correlation was found between existence of HPV in esophageal squamous carcinoma tissues and in grade Ⅰ, Ⅱ, Ⅲ esophageal squamous carcinoma cell.Conclusion HPV positive cells can be found in Hubei Zhongxiang and the other areas. The HPV infection might be, involved in the pathogenesis of squamous cell carcinoma of the esophagus in some regions.更多还原