【摘要】 目的:探讨多巴胺D2受体-141CIns/Del基因多态与线索诱发海洛因渴求程度的关系。方法:对戒断期380名海洛因依赖者实施线索诱发渴求实验,采用PCR-RFLP技术检测其DRD2-141CIns/Del基因多态,比较不同基因型与线索诱发海洛因渴求程度的关系。结果:DRD2-141CIns/Del三种多态基因型中,线索暴露前后海洛因渴求程度的差异均无显著性(P>0.05)。结论:DRD2-141CIns/Del基因多态可能与线索诱发海洛因渴求的易感性无关。更多还原

【Abstract】 Objective:To explore the relationship between DRD2 - 141C Ins/Del polymorphism and heroin craving. Methods:380 heroin addicts who were under abstinence were given the cue- elicited heroin craving experiment. And then we detected the polymorphism of DRD2- 141CIns/Del for them by using PCR- RFLP. We compared the relationship between genotypes of DRD2- 141CIns/Del and heroin craving before and after cue exposure. Results:No significant differ- ence has been found between heroin craving before and after cue- exposure in three genotypes of DRD2- 141CIns/Del. Conclusion:D2 receptor gene - 141CIns/Del polymorphisms may have no association with the susceptibility of heroin crav- ing.更多还原