【摘要】 目的评价阿奇霉素注射液治疗急性呼吸道感染、泌尿道感染及皮肤软组织感染的安全性和有效性。方法阿奇霉素注射液静脉滴注,每次250mg,每日1次,首次剂量加倍,疗程5d;对照药红霉素每日1g~1.5g,分1~2次静脉滴注,疗程7~14d。结果阿奇霉素注射液与红霉素随机对照治疗呼吸道、泌尿道及皮肤软组织感染134例,其中试验组69例,对照组65例。试验组与对照组的临床有效率(停药后1周)分别为94.2%与75.5%,细菌清除率分别91.9%与83.3%;不良反应发生率分别为8.45%与24.62%,以上结果经统计学处理有显著性差异(P<0.05)。结论阿奇霉素注射液静脉点滴,每次250mg,每日1次,首次剂量加倍,对敏感致病菌引起的轻、中度呼吸道感染,泌尿道感染及皮肤软组织感染均有很好临床疗效和细菌学疗效,不良反应发生率低。更多还原

【Abstract】 Objective To compare the clinical efficacy and safety of azithromycin injection and erythro-mycin injection in the treatment of moderate to severe bacterial infections. Methods A randomized controlled multi-center clinical trial was conducted for the treatment of hospitalized patients with respiratory tract infection, urinary tract infections and soft tissue infections. The dosage of azithromycin was intravanous infusion for 0.25g, once daily for 5 days and erythromycin 1～1.5g once or twice a day for 7～14 days. Results Results showed that the efficacy rates were 94.2% and 78.5%; the bacterial clearance rate were 91.9% and 83.3%; the incidence of adverse reaction were 8.45% and 24.62%, respectively. It showed that there was statistical difference between the two groups (P<0.05). Conclusion Azithromycin injection is a safe and effective drug in the treatment of respiratory tract infection, urinary tract infections and soft tissue infections.更多还原