【摘要】 目的探讨血浆同型半胱氨酸(HCY)测定在老年高血压及高血压合并2型糖尿病、高血压伴缺血性脑卒中患者中的临床意义。方法将90例老年高血压患者根据病史及体检分为单纯高血压组(30例),高血压伴缺血性脑卒中组(30例),高血压合并2型糖尿病组(30例);30名正常健康者作为对照组,4组患者进行血压、血脂、血糖、血浆HCY检测。结果单纯高血压组患者、高血压合并糖尿病组患者,高血压伴缺血性脑卒中组患者与对照组血浆HCY比较,差异有显著性意义(F=47.24,P<0.01);高血压合并糖尿病组患者与单纯高血压组血浆HCY比较差异有显著性(t=2.72,P<0.05);高血压伴缺血性脑卒中组患者与单纯高血压组患者血浆HCY比较差别有非常显著差异意义(t=4.08P<0.01);而高血压合并糖尿病组患者与高血压伴缺血性脑卒中组血浆HCY比较差异无显著差异意义(t=1.34,P>0.05),同时各组血压、血糖、血脂比较差异均无显著性意义(均P>0.05)。结论血浆HCY水平在老年高血压人群,尤其在高血压合并2型糖尿病、高血压伴缺血性脑卒中患者中明显升高,HCY的升高可能参与高血压的发生及造成血管病变,HCY是心脑血管疾病的独立危险因子。更多还原

【Abstract】 Objective To study the changes of homocysteine concentrations in old hypertension patiens patiens with diabetes and patiens with stroke. Methods 90 subjects were divided into 3 groups hypertension group30 hypertension with stroke group30 hypertension with diabetes group30. 30 healthy subjects were taken as nomal control group. Blood pressure lipid glucose and homocysteine were measured. Results When compared with nomal group blood homocysteine levels of hypertension group hypertension with stroke group hypertension with diabetes group were significantely differentF=47.24,P<0.01 compared with hypertension groupblood homocysteine levels of hypertension with diabetes group significantely differentt=2.72 P<0.05there was no significant difference on blood homocysteine levels between hypertension with stroke group and hypertension with diabetes groupt=1.34 P>0.05there were no significant difference on Blood pressure lipid glucose between the four groupsP>0.05. Conclution Homocysteine concentrations were manifest heighten in old hypertension patiensespecially in patiens with diabetes and patiens with stroke.更多还原