【摘要】 目的研究刺激性泻剂对大鼠肠道传输功能的影响。方法应用大黄和酚酞建立大鼠泻剂结肠模型,采用墨汁推进实验测定大鼠肠道传输功能。结果大黄组墨汁推进长度及百分比(黑染肠管长度/肠管总长度)与正常对照组相比明显缩小,差别有非常显著性意义(P<0.01);酚酞组与正常对照组相比也明显缩小,差别有显著性意义(P<0.05)。结论刺激性泻剂能明显减慢肠道传输,是加重和诱发便秘的一个重要因素。更多还原

【Abstract】 Objective To evaluate the effects of stimulant laxatives on intestinal transit function of rats. Methods A cathartic colon animal modal was established using rhubarb and phenolphthalein in rats. The intestinal transit function was studied with the ink pushing test. Results The pushing length and percentage were lower in the rhubarb and in the phenolphthalein groups than those in the normal group (P<0.01, P<0.05, respectively). Conclusion Stimulant laxatives can significantly decrease the intestinal transit speed and it may be an important factor in aggravating and evoking constipation更多还原