【摘要】 目的: 探讨一种从CT图像反求建模, 制造带有双循环系统 (微管循环和微孔循环 ) 的人工骨。方法: 采用狗股骨下段为对象, 应用Medical_Soft软件处理CT数据, 在Surfa cer软件中重构的狗股骨关节面, 并将数据输入Unigraphics软件中设计人工股骨下端三维模具,并且在人工骨模具内部设计立体微管结构。设计完成后生成STL文件并输入快速成型机加工。在模具内灌装磷酸三钙后烧结, 即得到带有双循环系统的人工骨。结果: 采用CT扫描资料建立起来的三维模型, 形态准确, 在这种模型的基础上, 灌装烧结的人工骨具有双循环系统, 微管大小 220 ~250μm,微孔大小 250~300μm, 孔内连接大小 50~100μm。结论: 个体化的人工骨三维模型的建立, 为人工骨的制造打下了良好的基础, 带有双循环系统的人工骨, 可以使生物活性物质 (生长因子、骨细胞 )、组织液渗透入人工骨深部, 缩短血管长入的时间, 从而新骨长入和成骨替代。更多还原

【Abstract】 Objective:To discuss a method of reverse engineering(RE) from computed tomography(CT), then make artificial bone with double circulated system (microcosmic pipeline cycle and microcosmic hole cycle).Method:CT scanned one femoral of dog,and the data was putted into Medical_Soft.Put the data into Unigraphics software to reconstruct the 3D model of the femoral.Then the authors designed some shelves in the model and put the model to the rapid prototyping machine for machining.After affusing TCP and calcine,gained the artificial bone with double circulated system.Result:The three-dimension(3D) model reconstructed by CT scan data objectively reflected the real figure, based on it,the authors made the artificial bone with double circulated system.The diameter of microcosmic pipeline was 220～250μm, microcosmic hole was 250～300μm,the connection among microcosmic holes was 50～100μm.Conclusion:The three-dimension(3D) model of individual artifical bone provides a good base to make artificial bone,the artificial bone with double circulated system can let the bioactive products(growth factor and osteocyte)and tissue fluid deep into the structure,it can reduce time of vessel growth,so it can make the artifical bone substituted by new bone.更多还原