【摘要】 目的: 研究血管内介入疗法防治骨折不愈合的作用。方法: 将 45只山羊的右胫骨中段截去 2. 5cm用钢板固定制成骨折不愈合模型, 随机分成血管内介入给药组、静脉全身给药组和对照组, 每组 15只, 术后 1周给药, 对照组不给药。分别应用单光子放射计算机断层成像术 (SPECT) 测定骨折端不同时相血流量变化, 摄X线片对比研究, 并取骨折端标本脱钙进行光镜和电镜观察。结果: 血管内介入给药组骨折端血流量在一定时间内较另两组明显增高 (P<0. 01 ), 且峰值期延长, 改良的X线Gary评分及组织学观察结果均优于静脉全身给药组和对照组。结论: 血管内介入疗法能增加骨折端血流量, 促进骨折愈合, 预防骨折不愈合形成。更多还原

【Abstract】 Objective: To study the effect of intravascualar interventional treatment on prevention of sheep tibial nonunion.Method: A nonunion model was created by cutting a 2.5cm middiaphyseal bone defect and stabilized by plate fixation in the right tibia of 45 sheep.Forty five sheep were divided randomly into 3 groups, 15 sheep in intravascular interventional group ,intravenous group and control group respectively and were given medicine a week after the fracture.The blood flow at the fracture site was measured by SPECT (Single Photon Emission Computerized Tomograrphy ) at different intervals after the fracture.X rays were taken and specimens were taken for light and electron microscope observation after decalcification .Result: The blood flow at the fracture sites increased more in the intravascular interventional group compared to the intravenous group and control group ( P <0.01) .The result of intravascular interventional group was superior to that of intravenous group and control group as were shown by X ray modified Gary′s radiographic scoring and microscope observation.Conclusion: Intravascular interventional treatment can increase the blood flow at the fracture sites, promote the fracture healing and prevent the formation of nonunion.更多还原