【摘要】 目的探讨胃癌患者焦虑和抑郁情绪反应对免疫调节功能的影响。方法89例经临床、影像学和病理确诊的胃癌患者分别接受Zung编制的抑郁自评量表(SDS)和焦虑自评量表(SAS)调查,并测定血清免疫球蛋白和外周血淋巴细胞亚群、淋巴因子等指标。结果89例胃癌患者中,焦虑患病率37%(33/89),SAS标准分均值明显高于正常人(P<0.05);抑郁患病率33%(29/89),SDS标准分均值明显高于正常人(P<0.05)。有焦虑、抑郁情绪胃癌患者的血清IgA、IgM,外周血淋巴细胞亚群中的CD3、CD4、CD8、CD4/CD8,淋巴因子IL2和TNFα均明显低于无不良情绪者各对应指标(P均<0.05)。结论胃癌患者有较明显的焦虑和抑郁情绪表现,这两种不良情绪与患者免疫调节功能密切相关。更多还原

【Abstract】 Objective To explore the influence of immune function by the emotion reaction of anxiety and depression in patients with gastric carcinoma.Methods 89 cases of patients with gastric carcinoma confirmed by clinic,photography and pathology were inquiried with SDS and SAS edited by Zung,and the blood immune globin,lymph cell subtribles and lymphokines were examined in the meantime.Results In the 89 cases,the patients with anxiety emotion reaction were 33 cases（33/89,37%）,and the SAS scores were higher than the normal（P<0.05）;the patients with depression emotion reaction were 29 cases（29/89,33%）,and the SDS scores were higher than the normal（P<0.05）.The blood IgA and IgM,CD₃,CD₄,CD₈,CD₄/CD₈ and lymphokines of IL-2,TNFα were lower in the patients with anxiety and depression emotion than those in the patients without anxiety and depression emotion（P<0.05）.Conclusion Patients with gastric carcinoma are easy to have anxiety and depression emotions which are associated with the function of immunity adjustion.更多还原