【摘要】 目的　探讨急性早幼粒细胞白血病(APL)的临床特点、最佳治疗方案、维A酸综合征(RAS)的防治。方法　分析18例APL患者的临床资料。结果　18例APL患者中以出血起病16例。维A酸联合化疗治疗8例,疗程>6周期2例,分别于第2 6个月、第72个月复发死亡;2例早期死亡;4例<4周期者2例无病生存5年以上,2例于5年后复发,治疗后再次完全缓解。维A酸、砷剂联合化疗治疗10例无病生存2～37个月。结论　APL是一种特殊类型急性白血病,临床以出血为主要症状,RAS以预防为主。更多还原

【Abstract】 Objective To explore clynical features,best optional therapy and retinoic acid syndrome of the patients with acute promyelocytic leukemia（APL）.Methods Analyzing clinical data of 18 patients with APL.Results Of the 18 cases,16 patients fell sick owing to hemrrohage.Among 8 cases treated in ATRA in combination with chemotherapy,2 cases whose therapeutic courses were more than 6 periods,one relapsed to death after 26 months,the other died after 72 months;2 died early;4 cases whose therapentic courses were less than 4 periods free-illness survived over five years,but 2 relapsed after five years after treatment,and gained complete remission again after being treated.10 cases treated in ATRA in combination with arsenic trioxide（As₂O₃） and chemotherapy were all free-illness survival of 2 to 37 months.Conclusion APL is a peculiar acute leukaemia whose main clinical syndrome is hemrrohoge,or DIC.Optional therapy still remains in dispute.Prevention is the main treatment in retinoic acid syndrome.更多还原