【摘要】 目的　观察再造尿道远期变化 ,对比不同材料的组织易感染性 ,研究如何降低尿道下裂术后感染率 ,探讨选择再造尿道组织材料的依据。方法　应用尿道镜、尿道造影观察再造尿道 ,以光镜、电镜观察再造尿道材料、再造尿道及正常尿道的组织切片。结果　应用皮肤、口腔黏膜、膀胱黏膜再造的尿道远期结构和易感染性均无变化 ,没有化生为尿道黏膜。结论　再造尿道壁远期仍与同源组织结构相同 ,组织易感染性相同。从微环境角度而言 ,膀胱黏膜和口腔黏膜是理想的再造尿道材料。皮肤再造的尿道具有内在固有的组织易感染特性。尿道下裂最佳手术年龄在青春期之前更多还原

【Abstract】 Objective Observing the long term results of reconstructed urethra to reduce the postop infection rate of hypospadias. To explore the standard of selecting tissue for urethra reconstruction by comparing the different inherent liability to infection in use of different kinds of tissue for urethra reconstruction. Methods Neo-urethra inner wall and normal urethra were observed through urography and urethroscope. The tissue section of neo-urethra, normal urethra and tissue for urethra reconstruction were observed through light microscope, scanning electron microscope and transmission electron microscope. Results The structure and liability to infection of neo-urethra made of bladder mucosa, buccal mucosa or skin never changed after long time. Metaplasia never took place in neo-urethra. Conclusions The structure and liability to infection of neo-urethra were the same as those of the congenetic tissue. Bladder or buccal mucosa is the best tissue for urethra reconstruction considering urethra microenvironment. Neo-urethra made of skin is more liable to infection by nature. The best opportunity of hypospadias operation should be before puberty. ;更多还原