【摘要】 目的探讨耐亚胺培南铜绿假单胞菌医院感染现状及其对13种常用抗菌药物的耐药性,指导临床合理选用抗菌药物。方法用常规方法对289株铜绿假单胞菌临床株进行鉴定,并采用Kirty-Bauer法选用13种抗菌药物进行药物敏感试验。结果106株耐亚胺培南铜绿假单胞菌的分离率为36.7%,主要来源于痰标本,占78.3%;其在临床病区分布中居前3位者依次为呼吸内科、神经外科、老年病科;106株铜绿假单胞菌对氯霉素、复方新诺明等8种抗菌药物均表现出>50%的耐药率。结论耐亚胺培南铜绿假单胞菌医院感染严重,对抗菌药物呈多重耐药,治疗此类细菌感染宜参考细菌药敏结果合理选用抗菌药物。更多还原

【Abstract】 OBJECTIVE To investigate the nosocomial status and drug resistance spectrum of imipenem-resistant Pseudomonas aeruginosa.METHODS VITEK32 was used for the identification of 289 P.aeruginosa clinical(isolates) and the resistance of 13 kinds antibiotics was determined by Kirby-Bauer method.RESULTS Totally 106 strains of imipenem-resistant P.aeruginosa were mainly isolated from departments of respiratory diseases,(neurosurgery) and geriatrics,most of them were from sputum(78.3%).Result of susceptibility test showed that P.aeruginosa was highly resistant to chloramphenicol,SMZ,etc.The trend of multidrug resistance of imipenem-resistant P.aeruginosa was increasing.CONCLUSIONS The status of nosocomial infection caused by imipenem-resistant P.aeruginosa is very serious, and these strains show multidrug resistance.To control this kind of(infection),we must choose antibiotic rationally according the result of(susceptibility) test.更多还原