【摘要】 目的探讨胃镜检查前咽部表面麻醉的有效性及与受检者耐受性的相关因素。方法采用随机双盲安慰剂对照的方法,纳入203例接受胃镜检查的患者。在取得所有受试者的知情同意下,采用Logistic回归分析咽部麻醉、焦虑和其他潜在的相关因素与患者不适程度的相对危险度(RR)。结果与安慰剂组比较,患者在胃镜插入时不适的相对危险度为0.37(95%CI 0.20-0.70), 患者年龄<40岁的相对危险度较≥40岁的患者高(RR=2.13,95%CI 1.09-4.15);对<40岁患者人群分析,咽部表面麻醉组及第一次接受胃镜检查患者发生不适的相对危险度分别为0.23(95%CI 0.07-0.77)和0.24(95%CI 0.10-0.58)。结论对<40岁和第一次接受胃镜检查者咽部表面麻醉能有效减轻不适,而焦虑特性与患者不适程度间无相关性。更多还原

【Abstract】 Objective To study on the efficiency of topical pharyngeal anesthesia in gastroscopy and the factors related to the tolerance of patients. Methods A randomized double-blind placebo-controlled study was conducted. Two hundred and three subjects consented to participate in this study underwent gastroscopy. Relative Risks (RR) of patients’ discomfort in pharyngeal anesthesia were calculated, anxiety and other potential confounding factors by using logistic regression analysis. Results Compared with placebo controls, the RR of patient discomfort on intubation was 0.37 (95 % CI 0. 20-0. 70) , patients aged less than 40 years had RR higher than those of aged 40 or over ( RR 2. 13 , 95% CI 1. 09-4. 15 ) . With subgroup analysis in those patients less than 40 years old and undergoing gastroscopy for the first time, the RR of patients’ discomfort was 0. 23 (95% CI 0. 07-0. 77) and 0. 24 (95% CI 0. 10-0. 58) for the topical anesthesia. Conclusion Topical pharyngeal anesthesia appears to be effective in diminishing the discomfort during endoscopy in patients less than 40 years old and those undergoing the procedure first time. Trait-anxiety is not a predictor of discomfort.更多还原