【摘要】 目的探讨过氧化物酶增殖物激活受体γ(PPARγ)与基质金属蛋白酶-7(MMP-7)与胃癌及癌前病变(轻度及重度异型增生)的关系。方法将胃镜活检及外科手术切除的胃组织标本分成4组,慢性胃炎组31例,轻度异型增生组25例,重度异型增生组27例,胃癌组28例,采用免疫组化检测PPARγ及MMP-7蛋白的表达,对结果进行统计分析。结果单独检测PPARγ与MMP-7,胃癌组的表达显著高于其他3组;联合检测PPARγ及MMP-7,两者在胃癌组及重度异型增生组的表达显著高于慢性胃炎组和轻度异型增生组。结论PPARγ和MMP-7是胃癌及胃癌前病变的重要标志,两者联合检测可对区分胃癌、重度异型增生与胃炎、轻度异型增生提供重要依据。更多还原

【Abstract】 Objective To investigate the relationships of peroxisome proliferators activated receptor γ(PPARγ) and matrix metallo protease-7 ( MMP-7) with gastric cancer ( including low and high grade atypical hyperplasia). Methods One hundred and twenty gastric tissue specimens (four groups) were collected by gastroscopy or surgical operation, including 31 patients with chronic gastritis, 25 patients with low-grade atypical hyperplasia, 27 patients with high-grade atypical hyperplasia, and 28 patients with gastric cancer. The expression of PPARγ and MMP-7 were observed by immunohistochemical technique and analyzed by statistic methods. Results Both of them have high expression in the groups of gastric cancer respectively, and the high combined expressions of them were found in gastric cancer and high-grade atypical hyperplasia. Conclusion PPARγ and MMP-7 were the important differential signs of the gastric cancer and precancer by inference, the combined expression of PPARγ and MMP-7 was the evidences in differential diagnosis among gastric cancer, high and low grade atypical hyperplasia and gastritis.更多还原