【摘要】 目的评价质子磁共振波谱(1H-MRS)在细菌性脑脓肿诊断及与颅内囊性及坏死性肿瘤鉴别诊断中的应用价值。方法对7例细菌性脑脓肿患者与19例颅内囊性、坏死性肿瘤患者进行1H-MRS检查,分析、比较共振峰的特点。结果7例细菌性脑脓肿患者中,6例显示多种氨基酸(AA)共振峰,5例出现丙氨酸(Ala)共振峰,2例出现乙酸(Ac)共振峰,1例出现琥珀酸(Suc)共振峰;上述波峰均未见于19例囊性、坏死性肿瘤患者。结论1H-MRS能有效反映细菌性脑脓肿与囊性、坏死性脑肿瘤的不同组织化学特征。依据AA、Ac、Suc及Ala共振峰的出现与否,1H-MRS能为细菌性脑脓肿的诊断与鉴别诊断提供非常有价值的信息。更多还原

【Abstract】 Objective To show the distinctive resonance pattern in 7 cases of intracranial abscess and 19 cases of cystic lesions as to evaluating these specific resonance peaks. Methods Characteristics of ~1H-MRS in 7 patients with brain abscesses and 19 with cystic or necrotic intracranial tumors were analyzed and compared. Peak assignment was based on reference values from in vivo and in vitro studies. Results Among 7 patients with brain abscesses, 6 showed the presence of cytosolic amino acid (AA) at 0.9 ppm, 5 showed alanine (Ala) at 1.5 ppm, 2 showed acetate (Ac) at 1.9 ppm and 1 patient showed succinate (Suc) at 2.4 ppm. None of the above resonances had been detected in spectra from 19 cases of cystic or necrotic intracranial tumors. Conclusions ~1H-MRS might reflect the different histochemical specificity of abscesses and cystic or necrotic tumors effectively. It should have special values in diagnosis and differential diagnosis of the brain abscess.更多还原