【摘要】 目的探讨家庭综合干预治疗对肿瘤晚期患者癌性疼痛的疗效及安全性。方法选取200例经病理确诊的肿瘤晚期患者,随机分为试验组和对照组各100例。试验组按照世界卫生组织(WHO)三阶梯止痛原则,给予家庭镇痛治疗,并进行家庭护理干预。对照组患者按照其自主择医镇痛的意愿,不增加干预。分别于初诊和治疗后4个月对两组患者进行疼痛强度、生活质量、心理功能以及医疗费用的评估并进行比较。结果试验组患者药物镇痛有效率为93%,对照组为78%,两者差异有统计学意义(P<0.01)。试验组生活质量、心理功能等方面有明显提高和改善(P<0.01),且优于对照组(P<0.01),同时总体医疗费用也低于对照组(P<0.05)。结论对肿瘤晚期患者癌性疼痛进行家庭综合干预治疗安全可靠,切实可行,镇痛效果好,值得推广。更多还原

【Abstract】 Objective To evaluate the effectiveness and safety of comprehensive analgesic and nursing care model available for the patients with advanced cancer at home.Methods Totally, 200 patients with pathologically diagnosed advaced cancer were randomly divided into 2 groups, with 100 patients in each of intervention and control groups. Patients in the intervention group were given analgesic treatment and nursing care at home, based on the principles of three-step pain management set by the World Health Organization (WHO) and patients in control group were treated at their own will without any special intervention. Intensity of pain, quality of life, psychologic function and medical expense of patients of 2 groups were evaluated and compared at their initial visits and visits after treatment for 4 months.ResultsThe efficiency of pain-relief was 93% in the intervention group and 78% in the control group (P<0.01), with significant improvement of quality of life,psychologic function and reduction of medical expense in the former than those in the latter (P<0.01, or P<0.05).Conclusion Comprehensive intervention with pain-relief drugs and nursing care at home was safe, effective and feasible for the patients with advanced cancer pain.更多还原