【摘要】 目的报道1例营养不良和免疫低下所引起的婴儿慢性皮肤黏膜念珠菌病。方法取患儿不同部位皮损标本直接镜检、真菌培养、相关菌学鉴定试验及分子生物学实验,确定致病菌种及药物敏感范围。结果患儿为5月女婴,大头貌,3个月前,无明显诱因在头、双耳廓、鼻孔、口腔、颈部、双腋下、臀部出现红斑、糜烂,表面结痂,伴瘙痒,头发、指趾甲生长不良。皮损刮取物进行真菌镜检和培养,发现臀部有白念珠菌生长,头屑有光滑念珠菌生长。淋巴细胞免疫表型分析CD16+566.5%,血清IgG6.74g/L,IgA321mg/L,血清白蛋白18g/L,均降低。提示患儿为低蛋白营养不良并存在免疫低下。结论结合喂养史、临床和实验室检查诊断为继发性营养不良所致婴儿慢性皮肤黏膜念珠菌病。更多还原

【Abstract】 Objective To investigate the clinical and laboratory profiles of a case of infantile chronic mucocutaneous candidiasis due to malnutrition.Methods Skin specimens were collected and examined by KOH preparation,fungus culture,biochemical tests and molecular biological study.The pathogenic strain and antimicrobial susceptibility were defined.Results A 5 month-old-girl was presented with big head,and erythema,erosion and crust on her head,auricles,nostrils,oral cavity,neck and buttocks,and itching,for 1 month.Dystrophic hair and nails were observed.Candida albicans was isolated from specimens of the buttocks and Candida glabrata from the scalp.The abnormalities,CD16+ (56 6.5%),serum IgG (6.74 g/L),IgA (0.321 g/L),and albumin (18 g/L) were found with flow cytometry and immunoassays.Conclusion The patient is diagnosed as infantile chronic mucocutaneous candidiasis,who is immunocompromised due to protein malnutrition.更多还原