【摘要】 分别采用电位滴定法、平衡溶解度法和摇瓶法,测定了石杉碱甲的解离常数、表观溶解度和表观油/水分配系数。结果表明石杉碱甲为一元弱碱,解离常数pKαT为6.18±0.02。随溶液pH的增加,表观溶解度下降,而表观油/水分配系数增大。更多还原

【Abstract】 Dissociation constant, apparent solubility and apparent partition coefficient of huperzine A in phosphoricbuffer solutions with different pH were determined by electric potential titration, equilibrium solubility method and shakeflask test, respectively. pKαT of huperzine A was 6.18 ± 0.02. With pH increase, apparent solubility was decreased whileapparent partition coefficient showed the increasing trend.更多还原