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肿瘤坏死因子α对人成骨样细胞NF-κB和护骨素表达的调节
Regulation of tumor necrosis factor-α on the expressions of nuclear factor-κB and osteoprotegerin in MG-63 cells
【摘要】 用肿瘤坏死因子α(TNF -α)干预培养的MG 63细胞(人成骨肉瘤来源)。结果显示:TNF -α上调MG 63细胞核蛋白p65表达,下调护骨素(OPG)mRNA和蛋白质表达。吡咯二硫氨基甲酸酯不能阻止TNF -α下调MG 63细胞OPG的作用。
【Abstract】 MG-63 cells (derived from human osteoblastoma) were treated with tumor necrosis factor-α (TNF-α). The results showed that TNF-α upregulated expression of nuclear protein p65 and downregulated expressions of OPG mRNA and protein, pyrrolidine dithiocarbamate did not abrogate the downregulation of OPG expression induced by TNF-α in MG-63 cells.
【关键词】 肿瘤坏死因子α;
NFκB;
护骨素;
MG63细胞;
【Key words】 Tumor necrosis factor-α; NF-κB; Osteoprotegerin; MG-63;
【Key words】 Tumor necrosis factor-α; NF-κB; Osteoprotegerin; MG-63;
【基金】 国家自然科学基金(39970347)
- 【文献出处】 中华内分泌代谢杂志 ,Chinese Journal of Endocrinology and Metabolism , 编辑部邮箱 ,2005年02期
- 【分类号】R58
- 【被引频次】4
- 【下载频次】158