【摘要】 目的探讨X线立体定向放射治疗老年人脑转移瘤疗效及并发症的相关因素。方法对老年脑转移瘤患者60例(120个脑转移灶)进行回顾性分析。77个转移灶采用立体定向放射治疗合并常规全脑放疗,43个转移灶单纯采用立体定向放射治疗。结果多因素分析脑转移瘤立体定向放射治疗疗效与体积及周边剂量有关。立体定向放射治疗并发症与体积有关。周边剂量(ED2Gy)>50Gy组的有效率为922%,明显高于≤50Gy组的722%(P<005),与此同时,并发症由0上升至196%(P<005);转移灶体积≤5ml组的有效率为955%,明显高于>5ml组的811%(P<001),与此同时,并发症由45%(3/67)增高至321%(17/53),二者比较差异有显著性(P<0001)。结论老年人脑转移瘤立体定向放射治疗有较好的疗效。体积及剂量是影响疗效和并发症的最重要的两个因素。更多还原

【Abstract】 Objective To evaluate the correlative factors of survival and complications of the elderly patients with brain metastasis in stereotactic radiosurgery. Methods A total of 120 metastatic brain tumors of 60 cases were analyzed retrospectively. Seventy-seven metastatic brain tumors were treated with stereotactic radiosurgery plus whole brain irradiation, and 43 metastatic brain tumors were treated with stereotactic radiosurgery only. Results In multivariate analysis, the tumor control rate for tumor volume ≤5 ml and >5 ml groups were 95.5% and 81.1% respectively. This difference was statistically significant (P<0.01). At the same time, the rate of complications for tumor volume ≤5 ml and >5 ml groups were 4.5 % and 32.1%, respectively (P<0.001). The tumor control rate for peripheral dose >50 Gy was increased statistically, but the occurrence of complications was also increased. Conclusions Stereotactic radiosurgery improves the outcome of the elderly patients with brain metastases. Radiation dosage and tumor volume are significantly related with the therapeutic efficacy and the occurrence of complications.更多还原