【摘要】 目的　研究铝对小鼠感觉运动行为和生活习性的影响。方法　健康雄性ICR小鼠经饮水中加入AlCl3 染毒,3个剂量组分别为10、50、300 mg·kg-1·d-1。通过自主活动、抓力、抓绳、平衡木、囤积食物、筑巢等实验观察铝对小鼠感觉运动行为和生活习性的影响。结果　10、50、300 mg·kg-1·d-1染铝组小鼠自主活动频数分别为(81.53±8.97)、(71.67±8.37)、(66.73±6.96)次,比对照组[(106.46±8.21)次]明显下降,差异有统计学意义(P<0.01),且染毒剂量与自主活动频数呈负相关(rs=-0.42,P<0.01)。50、300 mg·kg-1·d-1染铝组小鼠抓力转换分别为(19.19±1.48)、(13.36±1.46)分,比对照组[(24.31±1.43)分]明显降低,差异有统计学意义(P<0.05、P<0.01)。300 mg·kg-1·d-1染铝组小鼠囤积食物行为[96.10(90.20~99.00)g]与对照组[84.00(78.00~90.00)g]的差异有统计学意义(P<0.05)。其余指标各组差异不明显。结论　亚慢性染铝可以使小鼠自主活动行为减少、抓力降低、囤积食物行为改变(提示小鼠脑海马部位神经细胞损伤),但平衡协调能力未见影响。更多还原

【Abstract】 Objective To study the effect of aluminum chloride on motor and species-typical behaviors in mice. Methods Male ICR mice were administered with drinking double distilled water only containing AlCl 3 (10,50,300 mg·kg -1 ·d -1 ),and control group with drinking double distilled water only for 100 days.Spontaneous activity test,grip strength,beam traversal,tightrope task,food hoarding,and nest construction were used to study the effect of chloride aluminum on motor and species-typical behaviors in mice. Results The frequencies of spontaneous activity in low dose group,medium dose group and high dose group[(81.53±8.97), (71.67± 8.37), (66.73 ±6.96)times respectively] were lower than that in control[(106.46±8.21)times] ( P < 0.01) ,and were negatively correlated with doses( r s =-0.42, P <0.01).Grip strength scores in medium dose group(19.19± 1.48) and high dose group (13.36±1.46) respectively were lower than that in control(24.31±1.43)( P < 0.05, P <0.01).Food hoarding was greater in high dose group[96.10(90.20-99.00)g]than that in control group [84.00 (78.00-90.00)g( P <0.05)].The rest of parameters were of no statistical significance. Conclusion Subchronic exposure to AlCl 3 in mice may diminish motor activity and grip strength,but motor coordination was not impaired;alteration in food hoarding suggests damage to hippocampus cell.更多还原