【摘要】 目的分析研究我院10年来内镜诊断的反流性食管炎(RE)病例,评估10年来 RE 发病情况及与相关疾病的关系。方法 1995年1月至2004年12月经胃镜诊断的2088例原发性 RE,按洛杉矶分类进行分级,评估 RE 发病情况,分析患者年龄、性别和伴发疾病的关系。结果原发性 RE 占胃镜检查总人数的4.1%,男性多于女性(4.7%比3.2%,P=0.00).平均年龄55.34岁,男性发病年龄早于女性[(54.37±15.53)岁比(57.40±13.88)岁,P<0.01]。10年间年原发性 RE 检出率和发病年龄上升;随年龄增长 RE 检出率升高,病变程度加重。轻度的(A、B 级)占大多数(82.5%),在 RE 分级上男女差异无统计学意义(P>0.05)。RE 患者 Hp 阳性率低于受检人群(23.5%比42.3%,P<0.01)。Hp阳性 RE 检出率低于阴性(2.9%比4.7%,P<0.01)。Hp 阳性与阴性 RE 在 RE 分级上差异无统计学意义(P>0.05)。结论过去10年间,RE 患病率和发病年龄逐步上升,轻度的占大多数。RE 人群 Hp阳性率低于一般人群。更多还原

【Abstract】 Objective To investigate the prevalence of primary reflux esophagitis (RE) in our hospital during the past 10 years,and to study the relationship between various relevant factors and reflux disease.Methods Two thousands and eighty-eight patients with RE.diagnosed by endoscopy from January 1995 to December 2004,were graded according to Los Angeles Classification.The relationship between RE and age,gender and concomitant diseases were analyzed.Results RE was 4.1% of total endoscopy number.The prevalence of RE in males was higher than that in female (4.7% vs.3.2%,P<0.01).The mean age was 55.34 years old.The age of male patients was younger than that of female[(54.37±15.53) years vs.(57.40±13.88) years,P=0.00).The prevalence and mean age of RE patients were significantly increased during the past decade.Most of the patients (82.5%) had a mild grade of RE (grades A and B).It was no significant difference in severity grade between males and females(P>0.05).The prevalence of RE and proportion of severe RE were both increased with aging. H.pylori infection was less prevalent among the patients with RE (23.5%),comparing with non RE subjects (42.3%).The prevalence of RE in H.pylori-positive patients was lower than that in H. pylori-negative patients (2.9%vs.4.7%,P=0.00).The severity of RE was not correlated to H. pylori infection status (P>0.05).Conclusion The prevalence of RE was increased during the past 10 years.H.pylori infection was less prevalent among the patients with RE.更多还原