【摘要】 目的检测正常孕妇在各孕周血清抑制素A(Inhibin-A)的浓度,并探讨其与子痫前期发病的关系。方法采用酶联免疫吸附法(ELISA)检测691例正常孕妇及33例子痫前期孕妇外周血清中 Inhibin-A的水平,统计分析子痫前期孕妇与正常孕妇血清Inhibin-A中位数的差异。结果正常孕妇 Inhibin-A水平随孕周增加而逐渐升高,子痫前期孕妇血清Inhibin-A水平显著高于相同孕周正常孕妇的中位数。结论正常孕妇血清Inhibin-A浓度随妊娠进展逐渐增加,Inhibin-A浓度在子痫前期患者中明显升高。Inhibin-A升高对子痫前期发病有一定的指示作用。更多还原

【Abstract】 Objective To detect the concentrations of serum Inhibin-A of pregnant women in each gestational week, and to investigate the relationship between Inhibin-A level and the incidence of pre-eclampsia. Methods Serum samples were obtained from 691 healthy pregnant women and 33 pre-eclamptic pregnant women. Serum Inhibin-A was detected by ELISA. The difference of medians between normal pregnant women and pre-eclamptic pregnant women were compared. Results In normal maternal serum, the concentrations of serum Inhibin-A increased gradually with the process of pregnancy. The median of serum Inhibin-A levels of pre-eclamptic patients were significantly higher than that of normal pregnant women at the same gestational weeks. Conclusion The increase of serum Inhibin-A level is gradual with the process of pregnancy in normal pregnant women, while the serum Inhibin-A level rises significantly in pre-eclamptic pregnant patients. An elevated level of serum Inhibin-A may serve as a possible indicator for a higher risk of pre-eclampsia.更多还原