【摘要】 目的探讨骨髓形态学(包括细胞化学染色)在急性单核细胞白血病(AMLM5)和急性粒单核细胞白血病(AMLM4)形态学、免疫学及细胞遗传学(MIC)分型中的作用。方法对47例初治AML的骨髓穿刺标本进行形态学、免疫表型和染色体检查,并对检查结果进行分析。结果47例形态学诊断为AMLM4和AMLM5的患者最终经MIC分型诊断为AMLM525例;AMLM419例(其中AMLM4Eo5例);t(8;21)AML2例;T细胞性急性淋巴细胞白血病(TALL)1例。结论在AMLM4及AMLM5的MIC分型中,骨髓形态学仍具有重要的的诊断价值,免疫分型和染色体检查与形态学相互依存,有助于进一步提高诊断的准确率。更多还原

【Abstract】 Objective To explore the role of cytochemical staining in MIC(morphology,immunology and cytogenetics) typing of acute monocytic leukemia(AML-M5)and acute myelomonocytic leukemia (AML-M4). Methods We analyzed the characteristics of morphology,immunology and cytogenetics in 47 cases of diagnosed AML. Results Eventually,they were diagnosed with MIC.There were 25 cases with AML-M5,19 cases with AML-M4(consisted of 5 cases diagnosed AML-M4Eo),2 cases with acute myeloid leukemia with t(8∶21) and 1 case with T-ALL. Conclusions During MIC typing of AML-M4 and AML-M5, the diagnostic value of morphology remains important, for immunophenotype,cytogenetics and morphology are interdependent. Immunophenotype and cytogenetics are necessary for improvement of the accuracy rate of diagnosis.;更多还原