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护肾固精方预防大鼠同种慢性移植物肾病的研究

Efficacy of Hushen Gujing (HSGJ) in preventing chronicallograft nephropathy in rats

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【作者】 田晓辉薛武军王志勇周清发张寅生丁小明田普训

【Author】 TIAN Xiao-hui~1, XUE Wu-jun~1, WANG Zhi-yong~2, ZHOU Qing-fa~2, ZHANG Yin-sheng~1, DING Xiao-ming~1, TIAN Pu-xun~1(1.The Department of Renal Transplantation, The First Hospital of Xi’An JiaoTong University, Xi’an 710061, China;2.The Department of Traditional Chinese Medicine,The Second Hospital of Xi’An JiaoTong University, Xi’an 710004, China)

【机构】 西安交通大学第一医院西安交通大学第二医院西安交通大学第一医院 陕西西安710061陕西西安710061陕西西安710004陕西西安710061

【摘要】 目的:探讨护肾固精方对慢性移植物肾病的影响。方法:以Fisher大鼠作供者,Lewis大鼠作受者进行同种肾移植。移植后治疗组大鼠隔日给予护肾固精方饲喂。移植后16周作肾功能、移植肾组织学检测,测定肾组织中转化生长因子mRNA的表达。结果:与对照组比较,移植后治疗组24 h尿蛋白持续保持较低的水平(P<0.01),血清肌酐水平较低(P<0.01),肌酐清除率高(P<0.01);移植肾肾小球硬化程度轻(P<0.01),Banff评分低(P<0.01);转化生长因子β1(TGF-β1)的mRNA表达减少(P<0.01)。结论:护肾固精方对移植肾功能有保护作用,其机制与影响TGFβ1在移植肾的表达有密切关系。

【Abstract】 Objective: To evaluate the effect of HSGJ on chronic allograft nephropathy (CAN) using standard rat model of CAN. Method: Renal transplantation was performed with Fisher rats as donors and Lewis rats as recipients. All the recipients were randomly divided into control group and medication groups (high and low dosage of HSGJ, fed every other day). After 16 weeks of treatment, renal function and the histological alteration of CAN were measured. The expression of the TGFβ1 mRNA in the allograft was evaluated by real-time PCR. Result:The content of 24 h urine protein and the level of serum creatinine in the medication groups were significantly decreased (P<0.01) as compared with control group,whereas the creatinine clearance was increased(P<0.01). The degree of glomerular sclerosis and the Banff score of medication groups were lower than the control group respectively (P<0.01), in consistent with decreased expression of the TGF 1mRNA. Conclusion: HSGJ can prevent the chronic allograft nephropathy and the mechanism may be related with its influence on the expression of the TGFβ1.

【基金】 国家自然科学基金资助项目(30271623)
  • 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2005年17期
  • 【分类号】R285
  • 【被引频次】1
  • 【下载频次】56
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