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海洋真菌Alternalia sp.发酵液中化学成分的研究

Studies on constituents from the fermentation of Alternalia sp.

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【作者】 张海龙田黎付红伟裴月湖华会明

【Author】 ZHANG Hai-long1, TIAN Li2, FU Hong wei1, PEI Yue-hu1, HUA Hui-ming1 (1.School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, China; 2.First Institute of Oceanography,State Oceanic Administration,Qingdao 266003,China) [

【机构】 沈阳药科大学中药学院国家海洋局第一海洋研究所沈阳药科大学中药学院 辽宁沈阳110016山东青岛266003辽宁沈阳110016辽宁沈阳110016

【摘要】 目的研究海洋真菌Alternaliasp.菌株发酵液的化学成分,研究其成分对稻瘟霉的抑制情况,为从海洋微生物代谢产物中寻找新型抗真菌活性物质奠定基础。方法利用各种色谱技术进行分离,根据光谱数据鉴定结构。结果从中分离得到6个成分,分别鉴定为对苄氧基苯酚(Ⅰ),对羟基苯乙胺(Ⅱ),3羟甲基8羟基吡咯并哌嗪2,5二酮(Ⅲ),3异丁基6另丁基哌嗪2,5二酮(Ⅳ),5α,8α表二氧麦角甾6,22二烯3β醇(Ⅴ),3β羟基胆甾5烯(Ⅵ)。结论其中化合物Ⅰ,Ⅱ,Ⅲ,Ⅳ对稻瘟霉分生孢子或菌丝体有一定抑制作用;化合物Ⅰ,Ⅱ,Ⅲ为首次从本属菌中分离得到。

【Abstract】 Objective:To study the metabolites of marine fungus Alternalia sp. Method: Compounds were separated by column chromatography and their structures were elucidated by means of chemical and spectral analysis. Result: Six compounds were isolated from the ethyl acetate and n-butanol extracts of the fermentation of marine fungus Alternalia sp. Their structures were elucidated as p-benzyloxy-phenol (Ⅰ), p-hydroxy phenyl ethylamine(Ⅱ),3-hydroxymethyl-8-hydroxyl-pyrrolopiperazine-2, 5-dione (Ⅲ), 3-isobutyl-6-secbutyl-piperazine-2, 5-dione (Ⅳ), 5α, 8α-epidioxy-ergosta-6, 22-diene-3β-ol (Ⅴ), 3β-hydroxxy-cholesta-5-ene (Ⅵ). Conclusion: Compounds Ⅰ, Ⅱ, Ⅲ, Ⅳ have the activity of inducing morphological deformation of mycelia germinated from conidia of Pyricularia oryzae. Compounds Ⅰ, Ⅱ, Ⅲ were isolated from the genus Alternalia for the first time. [

【关键词】 海洋真菌抗真菌稻瘟霉
【Key words】 marine fungusantifungiPyricularia oryzae
【基金】 国家高技术研究发展计划(863项目)(2001AA624020)
  • 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2005年05期
  • 【分类号】TQ925
  • 【被引频次】26
  • 【下载频次】443
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