【摘要】 目的:探讨大黄对大鼠急性胰腺炎治疗作用的机理。方法:通过胰胆管逆行注射5 %牛磺胆酸钠制作大鼠急性胰腺炎模型,检测血清TNF -α、IL - 6水平及大黄治疗后的变化。结果:大黄治疗后AP大鼠血清TNF -α、IL - 6明显降低。结论:大黄通过降低血清TNF -α、IL - 6水平,可以对实验性急性胰腺炎的治疗产生一定的有益帮助更多还原

【Abstract】 Objective To evaluate the therapeutic mechanism of Rheum in acute pancreatitis(AP) Methods AP was induced by retrograde injection of 5% sodium taurocholate into the pancreatic duct in rats.The changes of blood (levels) of cytokine like IL-6,TNF-α and amylase and lipase were detected by RIA,and the pathologic changes of the pancreas studied by microscopy.Rheum decoction was given through the jejunum. Results ①Compared to the shame operated group,the AP group pancreatic rats,blood levels of AMY,LIP,IL-6,TNF-α increased significantly(P<0.05 or 0.01).The pancreas showed edematous,necrosis with inflammatory cell infiltration under light microscopy. ②Compared to the AP group,the blood levels of IL-6,TNF-α decreased significantly in various periods of rheum treatment. Conclusion Blood cytokine levels of IL-6,TNF-αin AP may be used as valuable parameters to evaluate the severity and prognosis of AP,serving as a theoretical basis in the treatment of AP with rheum.更多还原